深圳湾实验室张洋研究员于2022年8月4日应邀来深圳先进技术研究院进行学术交流，并作题为：“TMEM16F phospholipid scramblase mediates cell-cell fusion”的学术报告。Cell fusion is fundamental to the reproduction, development, and homeostasis of multicellular organisms. In addition to various cell type-specific fusogenic proteins, cell surface externalization of phosphatidylserine (PS), a universal eat-me signal in apoptotic cells, has been observed in different cell fusion events. Nevertheless, the molecular underpinnings of PS externalization and cellular mechanisms of PS-facilitated cell-cell fusion are unclear. Our lab report that TMEM16F, a Ca²⁺-activated phospholipid scramblase (CaPLSase), plays an essential role in placental trophoblast fusion by translocating PS to cell surface independent of apoptosis. We also identify one of the physiological activation mechanisms of TMEM16F in human trophoblast fusion. Our findings provide insight into understanding cell fusion mechanism of other cell types and demonstrate one approach to understand TMEM16F’s biological functions in wide-ranging physiological and pathological processes, including blood coagulation, bone mineralization, HIV infection, trophoblast fusion, and SARS-CoV2-mediated syncytialization.

张洋研究员与先进院老师学生交流

个人简介：张洋，深圳湾实验室特聘研究员，2014年获华中科技大学博士学位，2014-2015年任中科院深圳先进技术研究院助理研究员，2015-2022年就职于杜克大学医学院。2022年加入深圳湾实验室。他主要从事离子、磷脂跨膜转运的研究。课题组运用多种分子学方法，结合电生理、光学成像等技术手段，研究离子通道与磷脂翻转酶在生理与病理中的功能，为神经发育异常、凝血功能障碍、病毒感染等相关疾病提供治疗策略。先后在Neuron, Science Advances, eLife, IEEE Transactions on Medical imaging, PNAS, Cancer Discovery等期刊发表论文17篇。先后荣获Joy Cappel 青年科学家奖，Burroughs Wellcome Fund合作研究奖，Layton Holladay Memorial Fund基金会奖，Gordon Research Conference Best Poster Presentation奖等。