Research Center for Biomedical Optics and Molecular Imaging

Dr. Chengbo Liu, Professor, Researcher

Dr. Chengbo Liu is a Research Professor and PhD Supervisor at the Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, recognized with the National Science Fund for Excellent Young Scholars. As Assistant Director of the Institute of Biomedical and Health Engineering, he concurrently leads the Shenzhen Key Laboratory while serving on editorial boards for Photoacoustics (JCR Q1) and Biophotonics Discovery. A Xi'an Jiaotong University alumnus, he obtained his PhD in Biophysics (2012) following research training at Duke University (2009-2011). His team pioneered the development of zero-background targeted photoacoustic imaging and multi-scale systems spanning microscopic to macroscopic levels, achieving landmark human peripheral vascular visualization. With over 120 SCI publications (70+ as lead author in Science Advances, Nature Communications, etc.) garnering 4,000+ citations (H-index 40), he directs 20+ national projects including NSFC Major Programs and MOST Key R&D initiatives. His 20 granted invention patents underpin clinical translation through medical device ventures, complemented by editorial engagements with Nature Biomedical Engineering and peer review contributions to Science Advances and Nature Methods.

Dr. Jingqin Chen, Associate Researcher

Dr. Jingqin Chen is an Associate Research Professor and Master's Supervisor at the Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, recognized as a Shenzhen High-Level Talent and member of the CAS Youth Innovation Promotion Association. He obtained his PhD in Biochemistry and Molecular Biology from the University of Chinese Academy of Sciences, subsequently joining SIAT in 2014. His research training at the University of Texas at Austin (2019-2020) under Nobel laureate candidate Prof. Jonathan Sessler focused on molecular probe synthesis. Dr. Chen leads research in targeted regulation of inflammatory microenvironments and molecular theranostics, securing competitive grants including NSFC Youth/General Programs and CAS Youth Innovation Promotion funding. His 40+ SCI publications (18 as first/corresponding author in PNAS, JACS, Advanced Materials) have accumulated 1,600+ citations (H-index 21), supported by 5 invention patents. Collaborative contributions span national initiatives like the Key R&D Program and provincial grants, driving innovations in precision molecular diagnostics.

Dr. Rongkang Gao, Associate Researcher

Dr. Rongkang Gao is an Associate Research Professor and Master’s Supervisor at the Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, honored as a Shenzhen High-Level Talent. She serves on the editorial board of Photoacoustics (JCR Q1) and as a Youth Editorial Board Member for Biophotonics Discovery. Earning her PhD in Mechanical Engineering from the University of New South Wales in 2018, Dr. Gao joined SIAT later that year, where she leads pioneering work in photoacoustic theory, high-resolution/high-sensitivity imaging systems, and advanced computational algorithms. Her 20+ SCI publications (13 as first author in Laser & Photonics Reviews, Photoacoustics, and Physics of Fluids) reflect interdisciplinary innovations bridging optomechanics and biomedical imaging. Currently overseeing multiple grants including an NSFC project and Shenzhen Basic Research initiatives, she also contributes to China’s Key R&D Program as a core team member. With 13 patent applications advancing imaging technologies, Dr. Gao actively supports academic exchange through peer review for Photoacoustics and related journals, driving translational applications of optoacoustic diagnostics.

Dr. Yaguang Ren, Associate Researcher

Dr. Yaguang Ren is an Associate Research Professor at the Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences. She earned her Master’s degree in Optical Engineering from Tianjin University in 2013, where she developed high-precision optical detection systems using white-light interferometry and fiber-optic sensing. Transitioning to biomedical applications, Dr. Ren pursued her PhD in Bioengineering at the Hong Kong University of Science and Technology (2014-2018), specializing in advanced MRI reconstruction methodologies. Following her doctoral studies, she conducted pioneering single-molecule detection research through total internal reflection fluorescence resonance energy transfer (TIR-FRET) as a visiting scholar in life sciences. Since joining SIAT in 2019, her work has focused on developing multi-scale low-rank sparse reconstruction frameworks for cardiac photoacoustic imaging, bridging theoretical physics with clinical diagnostic applications. Her research trajectory spans optical metrology, computational biophysics, and translational medical imaging, consistently advancing precision measurement technologies across multiple biomedical domains.

Dr. Zhiqiang Xu, Associate Researcher

Dr. Zhiqiang Xu is an Associate Research Professor at the Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences. He earned his PhD in Information and Communication Engineering from Wuhan University of Technology in 2020, with research training at the University of Virginia during his doctoral studies. Specializing in multiscale high-speed photoacoustic microscopy, Dr. Xu develops innovative imaging frameworks to bridge microscopic resolution with macroscopic field-of-view capabilities. His first-author/corresponding-author contributions include 4 SCI-indexed papers and 3 conference proceedings, advancing real-time volumetric imaging for biomedical applications. Since joining SIAT in July 2020, he has pioneered rapid computational reconstruction algorithms and adaptive optoacoustic systems, pushing the boundaries of dynamic tissue visualization. His technical expertise spans optical system design, computational imaging, and translational medical device development, consistently addressing critical challenges in functional and molecular photoacoustics.

Dr. Song Zheng, PhD, Postdoctoral Researcher

Dr. Zheng Song is a Postdoctoral Researcher. He graduated with a PhD in Optics from Shanxi University in 2023, where his primary research focus was on all-optical photoacoustic imaging. He has published one SCI paper as the first author and holds one authorized Chinese patent. Dr. Song joined the Shenzhen Institutes of Advanced Technology, CAS, as a Postdoctoral Researcher in September 2023. His current research primarily focuses on single-pixel photoacoustic imaging.

Dr. Xiufeng Li, PhD, Postdoctoral Researcher

Dr. Xiufeng Li is a Postdoctoral Researcher. He received his PhD in Bioengineering from the Hong Kong University of Science and Technology in 2022, where his research primarily focused on ultraviolet photoacoustic pathological imaging and low-cost laser diode photoacoustic microscopy systems. Dr. Li has published 12 SCI papers, including 7 as the first or co-first author, and has applied for 8 invention patents, 2 of which have been authorized. In February 2024, Dr. Li joined the Shenzhen Institutes of Advanced Technology, CAS, as a Postdoctoral Researcher. His current research focuses on high-resolution 3D photoacoustic imaging.

Dr. Guangying Ma, PhD, Postdoctoral Researcher

Dr. Guangying Ma is a Postdoctoral Researcher. He received his PhD in Biomedical Engineering from the University of Illinois at Chicago in 2024, where his research focused on functional optical coherence tomography. Dr. Ma has published 15 SCI papers, including 5 as the first author. In June 2024, Dr. Ma joined the Shenzhen Institutes of Advanced Technology, CAS, as a Postdoctoral Researcher. His current research focuses on high-resolution 3D photoacoustic imaging.

Dr. Haoyang Chen, PhD, Postdoctoral Researcher

Dr. Haoyang Chen is an Assistant Researcher and Postdoctoral Researcher. He graduated with a PhD in Biomedical Engineering from Pennsylvania State University in 2024. In July 2024, he joined the Shenzhen Institutes of Advanced Technology, CAS, in collaboration with the National High-Performance Medical Device Innovation Center. Dr. Chen's doctoral research focused on the invention of transparent ultrasound transducers and their applications in ultrasound and photoacoustic microscopy and tomography, as well as brain functional imaging combining ultrafast ultrasound and photoacoustics. He has published over 20 high-level SCI papers and conference papers in internationally renowned academic journals, including 9 as the first or co-first author.

Dr. Xiangwei Lin, PhD, Postdoctoral Researcher

Dr. Xiangwei Lin, Senior Engineer & Shenzhen High-Level Talent at Shenzhen Institutes of Advanced Technology (CAS), holds a PhD from Harbin Institute of Technology (with a 2-year CSC-sponsored visit to University of Pittsburgh). His research focuses on ultrasound super-resolution, photoacoustic multimodality, deep learning, and beamforming algorithms. With 20+ high-level SCI papers (13 first-authored) and patents, he leads the NSFC Youth Project and China Postdoc Foundation (1st-Class Funding), and contributes to national instrument R&D and industry collaborations. Current interests: Next-gen ultrasound/photoacoustic systems, AI-driven imaging. Open to interdisciplinary partnerships in biomedical engineering & medical device innovation.

Chen Ningbo, PhD Candidate, Research Assistant

Chen Ningbo is a PhD candidate and Research Assistant. He graduated with a Master's degree in Mechanical Engineering from Guangzhou University in 2019. His current research focuses on the design of photoacoustic microscopy systems and their biomedical applications. He has published or co-published six journal papers, including those in Advanced Materials, Journal of Biophotonics, and Photoacoustics, and has applied for two Chinese invention patents.

Yang Wang, Research Assistant

Yang Wang is a Research Intern at the Shenzhen Institutes of Advanced Technology, CAS. He graduated with a Bachelor's degree in Measurement, Control Technology, and Instruments from Shandong University of Technology in 2018, and obtained a Master's degree in Biomedical Engineering from Southern Medical University in 2024. In May 2024, he joined the Shenzhen Institutes of Advanced Technology, CAS. His main research focuses on photoacoustic imaging theory and algorithms. He has published one journal paper and holds one invention patent.

Min Zhang, Research Assistant

Min Zhang graduated with a Bachelor's degree in Medicine from Southern Medical University. In 2021, she was admitted as a full-time Master's student in Laser Medicine at the General Hospital of the People's Liberation Army.In July 2023, she joined the Shenzhen Institutes of Advanced Technology, CAS. Her main research focuses on non-invasive phototherapy (low-level light) interventions for arthritis-related diseases and the exploration of underlying mechanisms. She also applies photoacoustic imaging technology for the diagnosis of arthritis inflammation and the evaluation of therapeutic effects following phototherapy interventions.

Liangjian Liu, PhD Candidate at University of Chinese Academy of Sciences

Liangjian Liu is a male PhD candidate. In 2013, he obtained a Bachelor's degree in Mechanical Design, Manufacturing, and Automation from the School of Mechatronics Engineering, Harbin Institute of Technology. He earned a Master's degree in Mechanical Engineering in 2015. In September 2018, he joined the Shenzhen Institutes of Advanced Technology, CAS, Institute of Biomedical and Health Engineering, focusing on the development of photoacoustic equipment. He has published over ten SCI articles and applied for more than ten invention patents.

Shirui Dong, PhD Candidate at University of Chinese Academy of Sciences

Shirui Dong is a male PhD candidate. In 2020, he graduated with a Bachelor's degree in Measurement, Control Technology, and Instruments from the School of Mechanical Engineering, Xi'an Jiaotong University. He obtained a Master's degree in Energy and Power Engineering from the School of Energy and Power Engineering, Xi'an Jiaotong University, in 2023. In September 2023, he joined the Shenzhen Institutes of Advanced Technology, CAS. His current research focuses on novel photoacoustic systems.

Weilei Ma, Direct PhD Candidate at University of Chinese Academy of Sciences

Weilei Ma was born on August 22, 2002. He is currently an undergraduate student majoring in Biomedical Engineering at the School of Control Science and Engineering, Shandong University. In January 2024, he joined the research group to complete his graduation project. In September 2024, he enrolled in the combined Master's and PhD program. His main research focus is on multi-view photoacoustic microscopic three-dimensional reconstruction algorithms. He enjoys music, sports, and travel.

Siyu Chen, Direct PhD Candidate at University of Chinese Academy of Sciences

Siyu Chen began his undergraduate studies in 2021, majoring in Electronic Information Engineering at the School of Information Science and Engineering, Yunnan University. In December 2024, he joined the research group to complete his graduation project and is scheduled to enroll in the combined Master's and PhD program in September 2025. His main research focus is on photoacoustic tomography algorithms. He has published one journal article and one conference paper.

Silue Zeng, Visiting PhD Candidate at Southern Medical University

Silue Zeng is a visiting PhD candidate in the Department of Surgery at Southern Medical University. In July 2020, he obtained a Master's degree in Surgery from Southern Medical University. In August 2020, he joined the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences. His current research focuses on the application of photoacoustic molecular imaging technology in hepatobiliary and pancreatic diseases. He has published multiple SCI and core journal papers, contributed to drafting two expert consensus documents on digital intelligent diagnosis and treatment technologies, and co-authored the monographs "Digital Cholecystectomy" and "Biliary Tract Surgery: Application of Digital Technology."

Zeyi Guo, Visiting PhD Candidate at Naval Medical University

Zeyi Guo is a visiting PhD candidate in Hepatobiliary Surgery at the Eastern Hepatobiliary Surgery Hospital, Naval Medical University. In July 2023, he graduated with a Master's degree in Surgery from Southern Medical University. In April 2024, he joined the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences. His current research focuses on the application of photoacoustic imaging for early diagnosis of microvascular invasion (MVI) in hepatocellular carcinoma. He has published multiple papers as the first author (including corresponding author) in journals such as Cellular Oncology, Journal of Tissue Engineering, and Chinese Journal of Clinical Oncology.

Tiancheng Lei, Visiting PhD Candidate at Sun Yat-sen University

Tiancheng Lei is a visiting PhD candidate at Sun Yat-sen University. In 2020, he joined the research group as an intern and completed his graduation thesis. He graduated from Nanjing University of Aeronautics and Astronautics in 2021 with a Bachelor's degree in Biomedical Engineering. In June 2021, he was admitted to the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, where he primarily focuses on photoacoustic microscopy imaging technology. He has published one journal paper and holds two invention patents. In June 2024, he graduated from the University of Chinese Academy of Sciences with a Master's degree in Biomedical Engineering. Currently, he is engaged in research on photoacoustic microscopy imaging technology and brain function.

Jinjin Cheng, Visiting Master's Student, Harbin Institute of Technology (Weihai)

Cheng Jinjin is currently a Master's student. She graduated in 2022 from Northeast Forestry University with a Bachelor's degree in Forest Engineering. In the same year, she was admitted to the Harbin Institute of Technology (Weihai) to pursue a Master's degree in Control Engineering. During her studies, she has been involved in the field of medical photoacoustic imaging.In July 2023, Cheng joined the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , where she primarily focuses on AI-based application algorithms in the medical field. In the summer of 2023, she interned with the Biophotonics Center at the Chinese Academy of Sciences, where she worked on post-processing algorithms for photoacoustic tomography imaging.

Chengjiong Zhang, Visiting Master's Student, Shenzhen University

Chengjiong Zhang is currently pursuing a Master's degree in Intelligent Manufacturing at Shenzhen University. He graduated in 2023 with a Bachelor's degree in Automation from Shenzhen University. In the same year, he was admitted to the Master's program in Intelligent Manufacturing at Shenzhen University. In July 2024, he joined the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences. He is currently involved in the development and research of photoacoustic microscopy imaging systems.

Taofeng Wu, Master's Student, University of Chinese Academy of Sciences

Taofeng Wu is currently pursuing a Master's degree. He joined the research group in December 2022 and completed his undergraduate thesis there. In 2023, he graduated from Guangzhou Medical University with a Bachelor's degree in Biomedical Engineering. In the same year, he was admitted to the Master's program at the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences. He is currently focused on the development of fast photoacoustic microscopy imaging technology and its related applications.

Xuyu Fu, Joint Master's Student, Southern University of Science and Technology

Xuyu Fu, born in 2002, is currently pursuing a Master's degree. He graduated with a Bachelor's degree in Intelligent Science and Technology from Sun Yat-sen University in June 2023. In 2024, he was admitted as a joint Master's student at Southern University of Science and Technology and joined the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, in May. His current research focuses on photoacoustic tomography and artificial intelligence technologies.

Jichao Zhang, Visiting Master's Student, Northeastern University

Jichao Zhang is currently pursuing a Master's degree in Control Engineering at Northeastern University as a visiting student. He graduated with a Bachelor's degree in Intelligent Science and Technology from Shenyang University of Technology in 2022. In 2023, he was admitted to the Master's program in Control Engineering at Northeastern University. In July 2024, he joined the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences. His current research focuses on photoacoustic computed tomography algorithms. In his free time, he enjoys sports.

Chuanmiao Yu, Joint Master's Student, Southern University of Science and Technology

Chuanmiao Yu is currently pursuing a Master's degree. He graduated from Shaanxi Normal University in 2024 with a Bachelor's degree in Engineering. In the same year, he was admitted to the joint Master's program between Southern University of Science and Technology and Shenzhen University of Technology. In September 2024, he joined the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences. His current research focuses on the application of photoacoustic imaging technology in animal disease models and the advancement of clinical projects.

Wenkai Li, Joint Master's Student, Shenzhen University

Wenkai Li is currently pursuing a Master's degree. He graduated from Tianjin Medical University in 2024 with a Bachelor's degree in Biomedical Engineering. In the same year, he was admitted to the joint Master's program between Shenzhen University and Shenzhen University of Technology. In September 2024, he joined the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences. His current research focuses on photoacoustic image processing algorithms.

Yuqing Lin, Visiting Master's Student, Shantou University Medical College

Yuqing Lin is currently pursuing a Master's degree. In 2024, she was admitted as a full-time Master's student in Imaging Medicine and Nuclear Medicine at Shantou University Medical College. In February 2025, she joined the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences. Her current research focuses on the early diagnosis and efficacy evaluation of autoimmune diseases using photoacoustic imaging technology.

Shuchang Li, Joint Master's Student, Southern University of Science and Technology

Shuchang Li is currently pursuing a Master's degree. She graduated with a Bachelor's degree in Food Science and Engineering from Jiangnan University in 2024. In the same year, she was admitted to the joint Master's program between Southern University of Science and Technology and Shenzhen University of Technology. In September 2024, she joined the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences. Her current research focuses on the application of photoacoustic imaging technology in diagnosing arthritis inflammation and evaluating the effects of drug treatments.

Xingyu Nie, Joint Master's Student, Shenzhen University

Xingyu Nie is currently pursuing a Master's degree. He graduated with a Bachelor's degree in Engineering from Nanjing University of Posts and Telecommunications in 2024. In the same year, he was admitted to the joint Master's program between Shenzhen University and Shenzhen University of Technology. In September 2024, he joined the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences. His current research focuses on bioinformatics for targeted studies of rheumatoid arthritis.

Novel Theories and Methods in Photoacoustic Tomography

    The generation of the photoacoustic effect involves multiple physical mechanisms, including photothermal conversion, heat conduction, thermoelastic expansion, pressure wave propagation, and temperature/ acoustic field distributions. Through the effective utilization and sophisticated manipulation of these physical mechanisms and phenomena, applications such as photoacoustic temperature extraction, super-resolution imaging, ultra-contrast imaging, photoacoustic-guided optical focusing, blood flow velocity measurement, and single-wavelength functional imaging have been realized, significantly expanding the scope of photoacoustic imaging technology. Meanwhile, the exploration of advanced imaging algorithms (e.g., virtual point synthetic aperture algorithm, deconvolution algorithm, forward projection, back-projection reconstruction algorithm, sound velocity compensation, filtered back-projection) has enabled super-resolution and deep-penetration photoacoustic 3D imaging, allowing photoacoustic imaging to achieve both "clearer visualization" and "deeper penetration." Currently, our laboratory is conducting research on novel theories and methods in photoacoustics from both physical mechanism and imaging algorithm perspectives. By improving the performance of photoacoustic imaging, we are actively expanding the application dimensions and scope of photoacoustic effects and technologies to drive further advancements in the field.

Photoacoustic Microscopy

     Photoacoustic microscopy technology enables label-free, high-resolution structural and functional imaging of living biological tissues using endogenous absorbers such as hemoglobin. It has been applied in multiple biomedical fields including neurology, ophthalmology, oncology, and dermatology. Our laboratory focuses on high-performance photoacoustic microscopy research, driving the advancement of this technology across three dimensions: equipment (high-speed, cross-scale, multi-modal systems), algorithms (signal denoising, image enhancement, vascular quantification), and applications (neurovascular coupling, tumor microenvironment analysis).

Photoacoustic Computed Tomography (PACT)

     Photoacoustic computed tomography (PACT) offers advantages such as high safety, high resolution, large imaging depth, and real-time imaging capabilities. It provides critical information on biological tissue structure, function, and metabolism, and has been proven to have significant application value in multiple biomedical fields. Our laboratory is dedicated to developing novel photoacoustic computed tomography instruments and application algorithms. Currently, we have developed two systems focusing on photoacoustic imaging of human peripheral blood vessels and photoacoustic imaging of small animals, which are expected to achieve greater breakthroughs in the field of biomedical imaging and provide rich and valuable information for the diagnosis, treatment, and efficacy evaluation of related diseases.

1.Photoacoustic Microscopy Technology and Instrumentation

2024

[112] Ningbo Chen, Zhiqiang Xu*, Zheng Song, Jiuling Liao, Hongdong Zhang, Jiahao Li, Taofeng Wu, Weileng Ma, Tiancheng Lei, Liangjian Liu, Guangying Ma, Hui Liao, Shiwei Ye, Jing Meng, Puxiang Lai, Yingjie Zhu, Kenneth K. Y. Wong, Hairong Zheng*, Wei Zheng*, and Chengbo Liu*. "Simultaneous head-mounted imaging of neural and hemodynamic activities at high spatiotemporal resolution in freely behaving mice" Science Advance 11, eadu11532025. (SCI, IF=11.7)

[111] Chaorui Qiu, Zhiqiang Zhang, Zhiqiang Xu, Liao Qiao, Li Ning, Shujun Zhang, Min Su, Weichang Wu, Kexin Song, Zhuo Xu, Longqing Chen, Hairong Zheng*, Chengbo Liu*, Weibao Qiu*& Fei Li*. "Transparent ultrasonic transducers based on relaxor ferroelectric crystals for advanced photoacoustic imaging" Nature Communicatons, 15:10580, 2024. (SCI, IF=14.7)

[110] Fengxian Du, Chen Niu, Silue Zeng, Jingqin Chen*, Chengbo Liu*, and Cuixia Dai*. "Contrast-enhanced near-infrared photoacoustic microscopy and optical coherence tomography imaging of rat fundus" Nanophotonics, 2024(SCI, IF=6.5)

[109] [Hongdong Zhang, Zhiqiang Xu, Ningbo Chen]¹, Fei Ma, Wei Zheng, Chengbo Liu*, and Jing Meng*. "Simultaneous removal of noise and correction of motion warping in neuron calcium imaging using a pipeline structure of self-supervised deep learning models" Biomedical Optics Express, 15(7):4300-4317, 2024. (SCI, IF =2.9)

[108] [Jing Meng, Jialing Yu]1, Zhifeng Wu, Fei Ma, Yuanke Zhang, Chengbo Liu*. "WSA-MP-Net: Weak-signal-attention and multi-scale perception network for microvascular extraction in optical-resolution photoacoustic microcopy" Photoacoustics, 37:100600, 2024, (SCI, IF=7.1)

[107] [Rongkang Gao, Yan Liu, Sumin Qi]¹, Liang Song, Jing Meng, and Chengbo Liu*. "Influence mechanism of the temporal duration of laser irradiation on photoacoustic technique: a review.”Journal of Biomedical Optics, 29:S11530, 2024. (SCI, IF=3.5) 

2022

[106]Huangxuan Zhao, Jia Huang, Qiang Zhou, Ningbo Chen, Liangjian Liu, Xinggang Wang, Tao Wang, Leqing Chen, Chengbo Liu*, Chuansheng Zheng*, Fan Yang*, "Deep Learning-Based Optical-Resolution Photoacoustic Microscopy for In Vivo 3D Microvasculature Imaging and Segmentation", Advanced Intelligent Systems, 4(9): 202200004, 2022 (SCI,IF=6.214)

[105] [Ningbo Chen, Jia Yu, Liangjian Liu]¹, Zhiqiang Xu, Rongkang Gao, Tao Chen, Liang Song, Wei Zheng*, and Chengbo Liu*, "Video-rate high-resolution single-pixel nonscanning photoacoustic microscopy", Biomedical Optics Express, 13(7): 3823-3835. 2022. (SCI,IF=3.732)

[104] [Yu Jiang, Xingchen Duan, Liangjian Liu]¹, Yang Shi*, Chengbo Liu*, Dan Ding, Yunfeng Deng*, Yang Han, Yanhou Geng*, "NIR-II-absorbing conjugated polymers based on tetra-fused isoindigo ribbons for photothermal conversion and photoacoustic imaging", Cell Reports Physical Science, 3: 100957, 2022. (SCI,IF=6.395)

[103] [Zhiqiang Xu, Yinhao Pan]¹, Ningbo Chen, Silue Zeng, Liangjian Liu, Rongkang Gao, Jianhui Zhang, Chihua Fang, Liang Song, Chengbo Liu*, "Visualizing tumor angiogenesis and boundary with polygon-scanning multiscale photoacoustic microscopy", Photoacoustics, 26: 100342, 2022. (SCI,IF=8.399)

[102]Jing Meng, Xueting Zhang, Liangjian Liu, Silue Zeng, Chihua Fang, and Chengbo Liu*, "Depth-extended acoustic-resolution photoacoustic microscopy based on a two-stage deep learning network", Biomedical Optics Express, 13(8): 4386-4397, 2022. (SCI, IF=3.732)

2021

[101] Weizhi Qi, Xiao Liang, Yaoyao Ji, Chengbo Liu, Lei Xi*, "Optical resolution photoacoustic computed microscopy", Optics Letters, 46(2): 372-375, 2021. (SCI, IF=3.776)

[100] [Huangxuan Zhao, Ke Li]¹, Fan Yang, Wenhui Zhou, Ningbo Chen, Liang Song, Chuansheng Zheng*, Zhicheng Liu* and Chengbo Liu*, "Customized anterior segment photoacoustic imaging for ophthalmic burn evaluation in vivo", Opto-Electronic Advances, 4(6): 200017, 2021. (SCI, IF=9.636)

[99]Huangxuan Zhao, Ziwen Ke, Fan Yang, Ke Li, Ningbo Chen, Liang Song, Chuansheng Zheng*, Dong Liang*, and Chengbo Liu*, "Deep Learning Enables Superior Photoacoustic Imaging at Ultralow Laser Dosages"，Advanced Science, 8(3): 2003097, 2021. (SCI, IF=15.840)

[98] Yinhao Pan, Ningbo Chen, Liangjian Liu, Chengbo Liu, Zhiqiang Xu* and Jianhui Zhang*, "Recovery of photoacoustic images based on accurate ultrasound positioning", Visual Computing for Industry, Biomedicine, and Art , 4(7): s42492-021-00072-2, 2021. (SCI, IF=3.2)

2020

[97] Huangxuan Zhao, Ke Li, Ziwen Ke, Ningbo Chen, Songjian Wang, Ke Li, Lidai Wang, Xiaojing Gong, Wei Zheng, Liang Song, Zhicheng Liu*, Dong Liang*, Chengbo Liu*, "A new deep learning method for image deblurring in optical microscopic systems". Journal of Biophotonics, 13(3): e201960147, 2020. (SCI, IF=3.914)

[96] Yingying Zhou, Siyi Liang, Mingsheng Li, Chengbo Liu, Puxiang Lai*, and Lidai Wang*, "Optical‐resolution photoacoustic microscopy with ultrafast dual‐wavelength excitation", Journal of Biophotonics, 13(6): e201960229. 2020. (SCI, IF=3.914)

[95] [Rongkang Gao, Hao Xu, Liangjian Liu]¹, Ying Zhang, Ting Yin, Huichao Zhou, Mingjian Sun, Ningbo Chen, Yaguang Ren, Tao Chen, Yinhao Pan, Mingbin Zheng, Tymish Y Ohulchanskyy, Rongqin Zheng, Lintao Cai, Liang Song, Junle Qu*, and Chengbo Liu*, "Photoacoustic visualization of the fluence rate dependence of photodynamic therapy," Biomed Optics Express, 11(8): 4203-4223. 2020. (SCI, IF=3.921)

[94] [Chen Zhang, Huangxuan Zhao, Song Xu]¹, Ningbo Chen, Ke Li, Xinkuan Jiang, Liangjian Liu, Zhicheng Liu, Lidai Wang, Kenneth K. Y. Wong, Jun Zou*, Chengbo Liu*, and Liang Song*,  "Multiscale high-speed photoacoustic microscopy based on free-space light transmission and a MEMS scanning mirror", Optics Letters, 45(16), 2020. (SCI, IF=3.714)

[93]Mingjian Sun, Chao Li, Ningbo Chen, Huangxuan Zhao, Liyong Ma, Chengbo Liu, Yi Shen, Riqiang Lin*, Xiaojing Gong*, "Full three-dimensional segmentation and quantification of tumor vessels for photoacoustic images", Photoacoustics, 20: 100212, 2020 (SCI, IF=5.870)

2019

[92] [Chengbo Liu, Jiuling Liao]¹, Longchao Chen, Jianhua Chen, Rubo Ding, Xiaojing Gong, Caimei Cui, Zhiqiang Pang, Wei Zheng*, Liang Song*, "The integrated high-resolution reflection-mode photoacoustic and fluorescence confocal microscopy." Photoacoustics, 14: 12-18, 2019. (SCI, IF=5.250)

[91] [Meng Zhou, Huangxuan Zhao]¹, Haibo Xia, Jiayao Zhang, Zhicheng Liu, Chengbo Liu*, Fei Gao*, "De-noising of photoacoustic sensing and imaging based on combined empirical mode decomposition and independent component analysis." Journal of Biophotonics, 12(8), 2019. (SCI, IF=3.768)

[90] [Qian Zhao, Riqiang Lin, Chengbo Liu]¹, Jingxiu Zhao, Guangtao Si, Liang Song*, Jing Meng*, "Quantitative analysis on in vivo tumor-microvascular images from optical-resolution photoacoustic microscopy." Journal of Biophotonics, 12(6): e201800421, 2019. (SCI, IF=3.768)

[89] Huangxuan Zhao, Ningbo Chen, Tan Li, Jianhui Zhang, Riqiang Lin, Xiaojing Gong, Liang Song, Kunya Zhang, Zhi Yang, Zhicheng Liu, Chengbo Liu*, "Motion Correction in Optical Resolution Photoacoustic Microscopy." IEEE Transactions on Medical Imaging, 38(9): 2139-2150, 2019. (SCI, IF=6.131)

[88][Ning Ding, Xiaoxiao Liu, Ningbo Chen]¹, Jing Jiang, Huangxuan Zhao, Zhigang Li*, Jianhui Zhang*, Chengbo Liu*, "Lack of association between acupoint sensitization and microcirculatory structural changes in a mouse model of knee osteoarthritis: A pilot study." Journal of Biophotonics, 12(6): e201800458, 2019. (SCI, IF=3.768)

[87] [Hui-Chao Zhou, Ningbo Chen]¹, Huangxuan Zhao, Tinghui Yin, Jianhui Zhang, Wei Zheng, Liang Song, Chengbo Liu*, Rongqin Zheng*, "Optical-resolution photoacoustic microscopy for monitoring vascular normalization during anti-angiogenic therapy", Photoacoustics, 15: 100143, 2019. (SCI, IF=5.25)

[86] Huangxuan Zhao, Ke Li, Ningbo Chen, Kunya Zhang, Lidai Wang, Riqiang Lin, Xiaojing Gong, Liang Song, Zhicheng Liu* and Chengbo Liu*, "Multiscale Vascular Enhancement Filter Applied to In Vivo Morphologic and Functional Photoacoustic", IEEE Photonics Journal, 11(6): 39009112, 2019. (SCI, IF=2.729)

2018

[85]  Huangxuan Zhao, Guangsong Wang, Riqiang Lin, Xiaojing Gong, Liang Song, Tan Li, Wenjia Wang, Kunya Zhang, Xiuqing Qian, Haixia Zhang, Lin Li, Zhicheng Liu*, Chengbo Liu*, "Three Dimensional Hessian matrix based quantitative vascular imaging of rat iris with optical-resolution photoacoustic microscopy." Journal of Biomedical Optics, 23(4)1-11, 2018. (SCI, IF=2.530)

2014

[84] Jing Meng, Chengbo Liu, Jiaxiang Zheng, Riqiang Lin, Liang Song*, “Compressed sensing based virtual-detector photoacoustic microscopy in vivo,” Journal of Biomedical Optics,19, 036003,  2014.  (SCI, IF=3.16)

[83] [Zhenyuan Yang, Jianhua Chen]¹, Junjie Yao, Riqiang Lin, Jing Meng, Chengbo Liu, Jinhua Yang, Xiang Li, Lihong Wang, Liang Song*, “Multi-parametric quantitative microvascular imaging with optical-resolution photoacoustic microscopy in vivo,” Optics Express, 22, 1500-1511. 2014.  (SCI, IF=3.59)

2.Photoacoustic Computed Tomography Technology

2024

[82] Jiwoong Kim, Joo Young Kweon, Seongwook Choi, Hyunseo Jeon, Minsik Sung, Rongkang Gao, Chengbo Liu*, Chulhong Kim*. and Yong Joo Ahn*, "Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo" Advanced Science, 09361, 2024. (SCI,IF =14.3)

[81] Rongkang Gao, Zhiqiang Xu & Chengbo Liu*,  "Fast capturing of deep blood flow | Nature Biomedical Engineering" Nature Biomedical Engineering, 8: 667–669(2024). (SCI,IF=26.8)

[80] Ning Wang, Tao Chen, Chengbo Liu*, Jing Meng*, "Intelligent skin‐removal photoacoustic computed tomography for human based on deep learning" Journal of Biophotonics, 17(10): 00197. 2024. (SCI, IF=2) 

[79] [Rongkang Gao, Yan Liu, Sumin Qi]¹, Liang Song, Jing Meng, and Chengbo Liu*, "Influence mechanism of the temporal duration of laser irradiation on photoacoustic technique: a review". Journal of Biomedical Optics, 29(S1): S11530-1, 2024. (SCI, IF=3)

2023

[78] [Rongkang Gao, Tao Chen, Yaguang Ren]¹, Liangjian Liu, Ningbo Chen, Kenneth K. Y. Wong, Liang Song, Xiaohui Ma, Chengbo Liu*, "Restoring the imaging quality of circular transducer array-based PACT using synthetic aperture focusing technique integrated with 2nd-derivative-based back projection scheme", Photoacoustics, 32: 100537, 2023. (SCI, IF=9.656)

[77] [Hai Zhang, Si-Lue Zeng, Yun-Zhu Wu, Ruo-Xin Zhang]¹, Liang-Jian Liu, Qiang Xue, Jing-Qin Chen, Kenneth K. Y. Wong, Jin-Feng Xu, Ya-Guang Ren*, Chi-Hua Fang*, and Cheng-Bo Liu*, "Handheld photoacoustic imaging of indocyanine green clearance for real-time quantitative evaluation of liver reserve function", Biomedical optics express, 14(7): 3610-3621, 2023. (SCI, IF=3.562)

2022

[76]Rongkang Gao, Qiang Xue, Yaguang Ren, Hai Zhang, Liang Song, Chengbo Liu*, "Achieving depth-independent lateral resolution in AR-PAM using the synthetic-aperture focusing technique", Photoacoustics, 26: 100328, 2022. (SCI, IF=8.484)

[75] [Yaguang Ren, Ying Zhang]¹, Honghui He, Liangjian Liu, Xiaojun Wu, Liang Song, Chengbo Liu*, "Optical fiber-based handheld polarized photoacoustic computed tomography for detecting anisotropy of tissues", Quantitative Imaging in Medicine and Surgery ,12(4): 2238-2246 , 2022. (SCI, IF=3.837)

2021

[74] [Tao Chen, Liangjian Liu, Xiaohui Ma]¹, Ying Zhang, Huadong Liu, Rongqin Zheng, Jie Ren, Huichao Zhou, Yaguang Ren, Rongkang Gao, Ningbo Chen, Hairong Zheng*, Liang Song*, Chengbo Liu*, "Dedicated photoacoustic imaging instrument for human periphery blood vessels: A new paradigm for understanding the vascular health", IEEE Transactions on Biomedical Engineering, 69(3): 1093-1100, 2021. (SCI, IF=4.538)

[73] Xueting Zhang, Fei Ma, Yuanke Zhang, Jiajun Wang, Chengbo Liu*, Jing Meng*, "Sparse-sampling photoacoustic computed tomography: Deep learning vs. compressed sensing", Biomedical Signal Processing and Control, 71:103233, 2021. (SCI, IF=3.880)

2020

[72] [Mingjie Gao, Guangtao Si]¹, Yuanyuan Bai, Lihong V. Wang, Chengbo Liu, and Jing Meng*, "Graphics processing unit accelerating compressed sensing photoacoustic computed tomography with total variation", Applied Optics, 59(3): 712-719. 2020. (SCI, IF=2.15)

[71] [Bing Cong, Chen Qiu, Yaguang Ren]¹,  Yuanyuan Bai, Muyue Xing, Tinghui Yin, Xiaojing Gong, Liang Song*, Rongqin Zheng*, Chengbo Liu*, "A low cost sensitive transrectal photoacoustic probe with single-fiber bright-field illumination for in vivo canine prostate imaging and real-time biopsy needle guidance", IEEE Sensors Journal, 20(18): 10974-10980, 2020. (SCI, IF=3.073)

2019

[70] Chengbo Liu, Muyue Xing, Bing Cong, Chen Qiu, Dong He, Congzhi Wang, Yang Xiao, Tinghui Yin, Min Shao, Weibao Qiu, Teng Ma, Xiaojing Gong, Xiong Chen, Hairong Zheng, Rongqin Zheng, Liang Song*, "In vivo transrectal imaging of canine prostate with a sensitive and compact handheld transrectal array photoacoustic probe for early diagnosis of prostate cancer." Biomedical Optics Express, 10(4): 1707-1717, 2019. (SCI, IF=3.482)

2018

[69] [Mucong Li, Chengbo Liu*]¹, Xiaojing Gong, Rongqin Zheng, Yuanyuan Bai, Muyue Xing, Xuemin Du, Xiaoyang Liu, Jing Zeng, Riqiang Lin, Huichao Zhou, Shouju Wang, Guangming Lu, Wen Zhu, Chihua Fang, Liang Song*, "Linear array-based real-time photoacoustic imaging system with a compact coaxial excitation handheld probe for noninvasive sentinel lymph node mapping." Biomedical Optics Express, 9(4): 1408-1422, 2018. (SCI, IF=3.337)

[68] [Xiangwei Lin, Chengbo Liu, Jing Meng]¹, Xiaojing Gong, Riqiang Lin, Mingjian Sun*, Liang Song*, "Dual-foci detection in photoacoustic computed tomography with coplanar light illumination and acoustic detection-A phantom study." Journal of Biomedical Optics, 23(5): 1-4, 2018. (SCI, IF=2.530)

[67] Yuanyuan Bai, Bing Cong, Xiaojing Gong, Liang Song, Chengbo Liu*, "Compact and low-cost handheld quasibright-field linear-array probe design in photoacoustic computed tomography", Journal of Biomedical Optics, 23(12): 121606, 2018. (SCI, IF=4.486)

[66] Jing Meng*, Chengbo Liu, Jeesu Kim, Chulhong Kim, and Liang Song*, "Compressed sensing with a gaussian scale mixture model for limited view photoacoustic computed tomography in vivo", Technology in Cancer Research & Treatment, 17: 1-11, 2018. (SCI, IF=2.8)

3. Photoacoustic Molecular Imaging

2024

[65] Silue Zeng, Jingqin Chen,* Rongkang Gao, Rui Chen, Qiang Xue, Yaguang Ren, Liangjian Liu, Chuanyu Tang, Haoyu Hu, Ning Zeng, Sai Wen, Hai Zhang, Chengbo Liu*, and Chihua Fang*, "NIR‐II Photoacoustic Imaging‐Guided Oxygen Delivery and Controlled Release Improves Photodynamic Therapy for Hepatocellular Carcinoma" Advanced Materials, 36(4):2308780, 2024. (SCI, IF=27.4)

[64] Wenguang Zhang, Miaomiao Kang, Xue Li, Hao Yang, Zhijun Zhang*, Zhuorong Li, Yibin Zhang, Miaozhuang Fan, Changrui Liao, Chengbo Liu, Gaixia Xu*, Dong Wang*, Zhourui Xu*, and Ben Zhong Tang*, "Interstitial Optical Fiber‐Mediated Multimodal Phototheranostics Based on an Aggregation‐Induced NIR‐II Emission Luminogen for Orthotopic Breast Cancer Treatment ", Advanced Materials, 36(38):2406474, 2024. (SCI,IF=27.4)

[63] Yingying Pan, Jingqin Chen*, Yuling Zhang, Yaguang Ren, Zhifeng Wu, Qiang Xue, Silue Zeng, Chihua Fang, Hai Zhang, Lingyan Zhang, Chengbo Liu* and Jie Zeng*, "Second Near-Infrared Macrophage-Biomimetic Nanoprobes for Photoacoustic Imaging of Neuroinflammation ", Molecular Pharmaceutics, 21(4): 1804-1816, 2024. (SCI,IF=4.5)

[62] [Qiang Xue, Silue Zeng, Yaguang Ren, Yingying Pan]¹, Jianhai Chen, Ningbo Chen, Kenneth K. Y. Wong, Liang Song, Chihua Fang, Jinghan Guo, Jinfeng Xu, Chengbo Liu, Jie Zeng, Litao Sun*, Hai Zhang*, and Jing Chen*, "Relief of tumor hypoxia using a nanoenzyme amplifies NIR-II photoacoustic-guided photothermal therapy ", Biomedical Optics Express, 15(1):59-76, 2024, (SCI, IF=2.9)

[61] [Jingqin Chen, Rui Chen, Calvin V Chau, Adam C Sedgwick]¹, Qiang Xue, Tao Chen, Silue Zeng, Ningbo Chen, Kenneth K Y Wong, Liang Song, Yaguang Ren*, Jian Yang*, Jonathan L Sessler*, Chengbo Liu*, "Targeted Cyclo[8]pyrrole-Based NIR-II Photoacoustic Tomography Probe for Suppression of Orthotopic Pancreatic Tumor Growth and Intra-abdominal Metastases", Journal of the American Chemical Society, 146(7): 4620-4631, 2024. (SCI, IF=15)

2023

[60] [Jian Li, Jiang-Nan Chen]¹, Zi-Xin Peng, Ning-Bo Chen, Cheng-Bo Liu, Peng Zhang*, Xu Zhang*, Guo-Qiang Chen*, "Multifunctional electrospinning polyhydroxyalkanoate fibrous scaffolds with antibacterial and angiogenesis effects for accelerating wound healing", ACS Applied Materials & Interfaces, 15(1): 364-377, 2023. (SCI, IF=10.383)

[59] Zong Chang, Liangjiang Liu, Jingying Zhai, Chenchen Liu, Xiao Wang, Chengbo Liu*, Xiaojiang Xie*, Qinchao Sun*, "Molecular Electronic Coupling-Induced Photoacoustics for NIR-I/II Duplex in Vivo Imaging", Chemistry of materials, 35(3): 1335-1344. (SCI, IF=10.508)

[58] Ruodan Lan, Jianxun Lv, Duyang Gao, Dehong Hu, Chunchen Liu, Jie Jia, Hairong Zheng, Chengbo Liu*, Ping Zhao*, Zonghai Sheng*, “Folate receptor-targeted nir-ii dual-model nanoprobes for multiscale visualization of macrophages in rheumatoid arthritis”, Advanced functional materials, 2023. (SCI, IF=19.924)

2022

[57] Jianhai Chen, Silue Zeng, Qiang Xue, Yuchuan Hong, Liangjian Liu, Liang Song, Chihua Fang, Hai Zhang, Benguo Wang, Adam C. Sedgwick, Peng Zhang, Jonathan L. Sessler*, Chengbo Liu* and Jingqin Chen*, "Photoacoustic image-guided biomimetic nanoparticles targeting rheumatoid arthritis", PNAS, 119 (43): e2213373119, 2022. (SCI, IF=12.779)

[56] [Yu Chen, Zhongzheng Yu]¹, Kai Zheng, Yaguang Ren, Meng Wang, Qiang Wu, Feifan Zhou, Chengbo Liu, Liwei Liu, Jun Song* and Junle Qu*, "Degradable mesoporous semimetal antimony nanospheres for near-infrared II multimodal theranostics", Nature Communications, 13: 539, 2022. (SCI, IF=14.919)

[55] [Yuejun Lin, Hui-chao Zhou]¹, Ningbo Chen, Yaguang Ren, Rongkang Gao, Qiaojia Li, Yiwen Deng, Xuejiao Han, Xiaoran Zhang, Andy Peng Xiang, Bing Guo*, Chengbo Liu* and Jie Ren*, "Unveiling the improved targeting migration of mesenchymal stem cells with CXC chemokine receptor 3-modifcation using intravital NIR-II photoacoustic imaging", Journal of Nanobiotechnology, 20(1): 307, 2022. (SCI, IF=9.913)

[54] [Xuewei Liu, Rongkang Gao, Chiyun Chen]¹, Xiaobo Li, Chen Yu, Yejia Chen, Hongbin Liang, Min Xiao, Lei Dai, Shifeng Qiu, Xiaoyu Xin, Liang Song, Jinbin Liu*, Chengbo Liu*, Jiancheng Xiu*, "Noninvasive photoacoustic computed tomography/ultrasound imaging for the identification of high-risk atherosclerotic plaques", European Journal of Nuclear Medicine and Molecular Imaging, 49(13): 4601-4615, 2022. (SCI, IF=9.236)

[53] [Rongkang Gao, Feng Liu]¹, Wenfeng Liu, Silue Zeng, Jingqin Chen, Ruru Gao, Liang Wang, Chihua Fang, Liang Song, Adam C. Sedgwick, Jonathan L. Sessler*, Jun Chu*, Fei Yan*, Chengbo Liu*, "Background-suppressed tumor-targeted photoacoustic imaging using bacterial carriers", PNAS, 119(8): e2121982119, 2022. (SCI, IF=12.779)

[52]Mingming Yin, Junwei Tong, Fanling Meng, Chenchen Liu, Xiaoming Liu, Fang Fang, Zhenyan He, Xiaojuan Qin, Chengbo Liu, Dong Ni, Yuting Gao*, Huageng Liang*, Xiaoping Zhang*, and Liang Luo*, "Near-infrared-II activatable symbiotic 2D carbon−clay nanohybrids for dual imaging-guided combinational cancer therapy", ACS applied materials & interfaces, 14(44): 49471–49482, 2022. (SCI, IF=10.383)

2021

[51]Yu Chen, Meng Wang, Kai Zhang, Yaguang Ren, Hao Xu, Zhongzheng Yu, Feifan Zhou, Chengbo Liu, Junle Qu, Jun Song*, "Antimony Nanopolyhedrons with Tunable Localized Surface Plasmon Resonances for Highly Effective Photoacoustic-Imaging-Guided Synergistic Photothermal/Immunotherapy", Advanced Materials, 33(18): 2100039, 2021. (SCI, IF=30.849)

[50] [Jingqin Chen, Adam Sedgwick, Sajal Sen]¹, Yaguang Ren, Qinchao Sun, Calvin Chau, Jonathan Arambula, Tridib Sarma*, Liang Song, Jonathan L. Sessler* and Chengbo Liu*, "Expanded porphyrins. Functional photoacoustic imaging agents that operate in the NIR-II region", Chemical Science, 29(12): 9916–9921, 2021. (SCI, IF=9.825)

[49] [Hui-Chao Zhou, Jie Ren]¹, Yuejun Lin, Duyang Gao, Dehong Hu, Tinghui Yin, Chen Qiu, Xiaoyan Miao, Chengbo Liu, Xin Liu, Hairong Zheng, Rongqin Zheng* and Zonghai Sheng*, "Intravital NIR-II three-dimensional photoacoustic imaging of biomineralized copper sulfide nanoprobes",  Journal of Materials Chemistry B, 9(13): 3005–3014,2021. (SCI, IF=6.331)

[48] Xingang Liu, Yukun Duan, Dehong Hu, Min Wu, Chengjian Chen, Pramila Baban Ghode, Gayathiri Magarajah, Nitish Thakor, Xin Liu, Chengbo Liu, Zonghai Sheng, Hairong Zheng*, and Bin Liu*, "Targeted Photoacoustic Imaging of Brain Tumor Mediated by Neutrophils Engineered with Lipid-Based Molecular Probe",  ACS Materials Letters, 3(9): 1284-1290, 2021. (SCI, IF=8.484)

[47] [Dongsheng Yua, Yazhou Wanga, Jifeng Chen]¹,  Shuang Liu, Shaohui Deng, Chengbo Liu, Iain McCulloch, Wan Yue*, Du Cheng*, "Co-delivery of NIR-II semiconducting polymer and pH-sensitive doxorubicin-conjugated prodrug for photothermal/chemotherapy", Acta Biomaterialia, 2021. (SCI, IF=8.947)

[46] [Jingqin Chen, Adam C. Sedgwick, Sajal Sen]¹, Yaguang Ren, Qinchao Sun, Calvin Chau, Jonathan F. Arambula, Tridib Sarma*, Liang Song, Jonathan L. Sessler* and Chengbo Liu*, "Expanded porphyrins: functional photoacoustic imaging agents that operate in the NIR-II region", Chemical Science, 12(29): 9916–9921, 2021. (SCI, IF=9.969）

2020

[45] [Zhihua Xie, Yanqing Yang, Yaqiong He]¹,  Chengyou Shu, Dong Chen, Jinke Zhang, Jingqin Chen, Chengbo Liu, Zonghai Sheng, Huadong Liu, Jie Liu*, Xiaojing Gong*, Liang Song*, Shaohong Dong*, "In vivo assessment of inflammation in carotid atherosclerosis by noninvasive photoacoustic imaging", Theranostics,10(10): 4694-4704, 2020 (SCI, IF=8.063)

[46] [Chaobang Zhang, Rongkang Gao]¹, Liangliang Zhang, Chengbo Liu*, Zhengmin Yang, and Shulin Zhao*, "Design and synthesis of a ratiometric photoacoustic probe for in situ imaging of zinc Ions in deep tissue in vivo", Analytical Chemistry, 92 (9): 6382-6390, 2020. (SCI, IF=5.15)

[43] [Jingqin Chen, Ji Qi, Chao Chen]¹, Jianhai Chen, Liangjian Liu, Rongkang Gao, Tiantian Zhang, Liang Song, Dan Ding*, Peng Zhang*, and Chengbo Liu*, "Tocilizumab-conjugated polymer nanoparticles for NIR-II photoacoustic imaging-guided therapy of rheumatoid arthritis", Advanced Materials, 32(37): e2003399. 2020. (SCI, IF=27.398)

[42] Yaxin Hu, Shan Xue, Peizhao Lyu, Xinyu Zhang, Jingqin Chen, Siping Chen, Chengbo Liu*, Xin Chen*, "Opto-acoustic Synergistic Irradiation for Vaporization of Natural Melanin-cored Nanodroplets at Safe Energy Levels and Efficient Sono-chemo-photothermal Cancer Therapy", Theranostics, 10(23): 10448-10465, 2020.(SCI,IF=8.579)

[41]Chen Qiu, Yuanyuan Bai, Tinghui Yin, Xiaoyan Miao, Rongkang Gao, Huichao Zhou, Jie Ren, Liang Song, Chengbo Liu, Hairong Zheng, Rongqin Zheng*, "Targeted imaging of orthotopic prostate cancer by using clinical transformable photoacoustic molecular probe", BMC Cancer, 20(1), 2020(SCI, IF=2.933)

[40] [Yaguang Ren, Adam C. Sedgwick, Jingqin Chen]¹, Gregory Thiabaud, Calvin V. Chau, Jusung An, Jonathan F. Arambula, Xiao-Peng He, Jong Seung Kim*, Jonathan L. Sessler*, and Chengbo Liu*, "Manganese(II) Texaphyrin: A Paramagnetic Photoacoustic Contrast Agent Activated by Near-IR Light", Journal of the American Chemical Society, 142(38): 16156-16160, 2020. (SCI, IF=14.612)

2019

[39] [Yanqing Yang, Jingqin Chen]¹, Yuming Yang,Zhihua Xie, Liang Song, Peng Zhang*, Chengbo Liu*, Jie Liu*, "A 1064 nm excitable semiconducting polymer nanoparticle for photoacoustic imaging of gliomas." Nanoscale, 11: 7754-7760, 2019. (SCI, IF=7.233)

[38] [Shan Sun, Jingqin Chen]¹,  Kai Jiang, Zhongdi Tang, Yuhui Wang, Zhougjun Li, Chengbo Liu*, Aiguo Wu*, Hengwei Lin*, "Ce6-Modified Carbon Dots for Multimodal-Imaging-Guided and Single-NIR-Laser-Triggered Photothermal/Photodynamic Synergistic Cancer Therapy by Reduced Irradiation Power." ACS Applied Materials & Interfaces, 11(6): 5791-5803, 2019. (SCI, IF=8.097)

[37] Huixiang Yan, Jingqin Chen, Ying Li, Yuanyuan Bai, Yunzhu Wu, Zonghai Sheng, Liang Song, Chengbo Liu*, Hai Zhang*, "Ultrasmall hybrid protein-copper sulfide nanoparticles for targeted photoacoustic imaging of orthotopic hepatocellular carcinoma with high signal-to-noise ratio." Biomaterials Science, 7(1): 92-103, 2019. (SCI, IF=5.831)

[36] [Bing Guo, Jingqin Chen, Ningbo Chen]¹, Eshu Middha, Shidang Xu, Yutong Pan, Chengbo Liu*, Bin Liu*, "High-Resolution 3D NIR-II Photoacoustic Imaging of Cerebral and Tumor Vasculatures Using Conjugated Polymer Nanoparticles as Contrast Agent." Advanced Materials, 31(25), 2019. (SCI, IF= 21.95)

[35] Qingshan Chen, Jingqin Chen, Mu He, Yuanyuan Bai, Huixiang Yan, Ning Zeng, Fangyan Liu, Sai Wen, Liang Song, Zonghai Sheng*, Chengbo Liu* and Chihua Fang*, "Novel small molecular dye-loaded lipid nanoparticles with efficient near-infrared-II absorption for photoacoustic imaging and photothermal therapy of hepatocellular carcinoma", Biomaterials Science, 7(8): 3165-3177, 2019. (SCI, IF=5.251)

2018

[34] Dehong Hu, Zonghai Sheng*, Mingting Zhu, Xiaobing Wang, Fei Yan, Chengbo Liu, Liang Song, Ming Qian, Xin Liu, Hairong Zheng*, "Förster Resonance Energy Transfer-Based Dual-Modal Theranostic Nanoprobe for In Situ Visualization of Cancer Photothermal Therapy", Theranostics, 8(2): 410-422, 2018(SCI, IF=8.766)

[33]  Jingqin Chen, Xueshen Li, Xiaoyang Liu, Huixiang Yan, Zhihua Xie, Zonghai Sheng, Xiaojing Gong, Lidai Wang, Xin Liu, Peng Zhang, Hairong Zheng, Liang Song, Chengbo Liu*, "Hybrid MoSe2-indocyanine green nanosheets as a high-efficient phototheranostic agent for photoacoustic imaging guided photothermal cancer therapy." Biomaterials Science, 6, 1503-1516, 2018. (SCI, IF=4.210)

[32][Chengbo Liu, Jingqin Chen, Ying Zhu]¹, Xiaojing Gong, Rongqin Zheng, Ningbo Chen, Dong Chen, Huixiang Yan, Peng Zhang, Hairong Zheng, Zonghai Sheng*, Liang Song*, "Highly sensitive MoS2-Indocyanine green hybrid for photoacoustic imaging of orthotopic brain glioma at deep site." Nano-Micro Letters, 10(3), 2018. (SCI, IF=4.849)

[31] Meiying Wu, Wenting Chen, Yu Chen, Haixian Zhang, Chengbo Liu, Zhiting Deng, Zonghai Sheng, Jingqin Chen, Xin Liu, Fei Yan*, Hairong Zheng*, "Focused Ultrasound-Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging-Guided Brain Tumor Treatment" Advanced Science, 5(4), 1700474, 2018. (SCI, IF=2.530)

[30] [Xiangwei Lin, Chengbo Liu]¹, Zonghai Sheng, Xiaojing Gong, Liang Song, Ruifang Zhang, Hairong Zheng*, Mingjian Sun*, "Highly Sensitive Fluorescence and Photoacoustic Detection of Metastatic Breast Cancer in Mice Using Dual-Modal Nanoprobes", ACS Appl. Mater. Interfaces, 10(31): 26064−26074, 2018. (SCI, IF=8.097)

[29] [Wenxiang Xu, Jingqin Chen, Shan Sun]¹, Zhongdi Tang, Kai Jiang, Liang Song, Yuhui Wang*, Chengbo Liu*, Hengwei Lin*, "Fluorescent and photoacoustic bifunctional probe for the detection of ascorbic acid in biological fluids, living cells and in vivo", Nanoscale, 10(37): 17834-17841, 2018. (SCI, IF=7.233)

[28] Zonghai Sheng, Bing Guo, Dehong Hu, Shidang Xu, Wenbo Wu, Weng Heng, Liew Kui Yao, Jingying Jiang, Chengbo Liu, Hairong Zheng*, Bin Liu*, "Bright Aggregation‐Induced‐Emission Dots for Targeted Synergetic NIR‐II Fluorescence and NIR‐I Photoacoustic Imaging of Orthotopic Brain Tumors", Advanced Materials, 30(29): 1800766, 2018. (SCI, IF=27.398)

[27] Bing Guo, Zonghai Sheng, Dehong Hu, Chengbo Liu, Hairong Zheng,* and Bin Liu*, "Through Scalp and Skull NIR-II Photothermal Therapy of Deep Orthotopic Brain Tumors with Precise Photoacoustic Imaging Guidance", Advanced Materials, 30(35):1802591, 2018. (SCI, IF=27.398)

[26] Guiying Xu, Xin Bao, Jingqin Chen, Bohan Zhang, Di Li, Ding Zhou, Xiaoyun Wang, Chengbo Liu, Yingli Wang*, and Songnan Qu*, "In Vivo Tumor Photoacoustic Imaging and Photothermal Therapy Based on Supra-(Carbon Nanodots)", Advanced Healthcare Materials, 8(2): 1800995, 2018. (SCI, IF=7.367)

[25] Xin Bao, Ye Yuan, Jingqin Chen, Bohan Zhang, Di Li, Ding Zhou, Pengtao Jing, Guiying Xu, Yingli Wang, Kateřina Holá, Dezhen Shen, Changfeng Wu, Liang Song, Chengbo Liu*, Radek Zbořil* and Songnan Qu*, "In vivo theranostics with near-infraredemitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration", Light-Science & Applications, 7(91), 2018, (SCI, IF=13.714)

[24] Yi Huang, Xiaoxia Li, Lu Zhang, Xiaoyan Chen, Chengbo Liu, Jingqin Chen, Yong Wang*, and Xintao Shuai, "Multifunctional Nanoplatform Based on pH-responsive Micelle Coated with Discontinuous Gold Shell for Cancer Photothermo-chemotherapy and Photoacoustic Tomography", Chinese Journal of Polymer Science, 36: 1139–1149, 2018. (SCI, IF=3.154)

2017

[23] Bing Guo, Zonghai Sheng, Dehong Hu, Chengbo Liu, Hairong Zheng*, Bin Liu*, "Biocompatible Conjugated Polymer Nanoparticles for Highly Efficient Photoacoustic Imaging of Orthotopic Brain Tumor in Second Near-Infrared Window", Materials Horizons, 4(6): 1151-1156, 2017 (SCI, IF=10.706).

[22] Bing Guo, Zonghai Sheng, Dehong Hu, Anran Li, Shidang Xu, Purnima Naresh Manghnani, Chengbo Liu, Lin Guo, Hairong Zheng*, Bin Liu*, "Molecular Engineering of Conjugated Polymers for Biocompatible Organic Nanoparticles with Highly Efficient Photoacoustic and Photothermal Performance in Cancer Theranostics", Acs Nano., 11(10): 10124-10134, 2017 Oct 24. (SCI, IF=13.942).

[21]Mingting Zhu, Zonghai Sheng, Yali Jia, Dehong Hu, Xin Liu, Xianyuan Xia, Chengbo Liu, Pan Wang, Xiaobing Wang*, Hairong Zheng*, "Indocyanine Green-holo-Transferrin Nanoassemblies for Tumor-Targeted Dual-Modal Imaging and Photothermal Therapy of Glioma", ACS Applied Materials & Interfaces, 9(45): 39249-39258, 2017 (SCI, IF=7.502).

2016

[20] [Jingqin Chen  , Chengbo Liu]¹, Dehong Hu  , Feng Wang  , Haiwei Wu  , Xiaojing Gong , Xin Liu  , Liang Song*  , Zonghai Sheng*  , Hairong Zheng*,   "Single-Layer MoS2 Nanosheets with Amplified Photoacoustic Effect for Highly Sensitive Photoacoustic Imaging of Orthotopic Brain Tumors", Advanced Functional Materials, 26(47): 8715-8725, 2016. (SCI, IF=11.382)

[19] Dehong Hu, Chengbo Liu, Liang Song, Haodong Cui, Guanhui Gao, Peng Liu, Zonghai Sheng*, Lintao Cai*, "Indocyanine green–loaded polydopamine–iron ions coordination nanoparticles for photoacoustic/magnetic resonance dual-modal imaging-guided cancer photothermal therapy", Nanoscale, 8(39): 11750-11758, 2016. (SCI, IF=7.760)

[18] Chengbo Liu, Xiaojing Gong, Riqiang Lin, Feng Liu, Jingqin Chen, Zhiyong Wang, Liang Song*, Jun Chu*, "Advances in imaging techniques and genetically encoded probes for photoacoustic imaging". Theranostics, 6(13): 2414-2430 (2016).（SCI, IF=8.854）

[17] Junwei Li, Hong Xiao, Soon Joon Yoon, Chengbo Liu, Drew Matsuura, Wanyi Tai, Liang Song*, Matthew O'Donnelll*, Du Cheng*, Xiaohu Gao*, "Functional Photoacoustic Imaging of Gastric Acid Secretion Using pH-Responsive Polyaniline Nanoprobes." Small. (SCI, IF=8.31)

[16]Jingqin Chen, Chengbo Liu, Guang Zeng, Yujia You, Huina Wang, Xiaojing Gong, Rongqin Zheng, Jeesu Kim, Chulhong Kim, Liang Song*, "Indocyanine Green Loaded Reduced Graphene Oxide for In Vivo Photoacoustic/Fluorescence Dual-Modality Tumor Imaging", Nanoscale Research Letters, 11(1), 85-88(2016). (SCI, IF=2.779)

2015

[15][Juan Mou, Chengbo Liu]¹, Pei Li, Yu Chen, Huixiong Xu, Chenyang Wei¹, Liang Song, Jianlin Shi*, Hangrong Chen*, "A Facile Synthesis of Versatile Cu2-xS Nanoprobe for Enhanced MRI and Infrared Thermal/Photoacoustic Multimodal Imaging,"Biomaterials, 57, 12-21(2015) (SCI, IF=8.312)

[14] Juan Mou, Pei Li, Chengbo Liu, Huixiong Xu, Liang Song, Jin Wang, Kun Zhang, Yu Chen, Jianlin Shi, Hangrong Chen, "Ultrasmall Cu2-xS Nanodots for Highly Efficient Photoacoustic Imaging-Guided Photothermal Therapy." Small, 11(19), 2275-2283(2015) (SCI, IF=7.514)

[13] Duyang Gao, Pengfei Zhang, Chengbo Liu, Chi Chen, Guanhui Gao, Yayun Wu, Zonghai Sheng, Liang Song, Lintao Cai, "Compact chelator-free Ni-integrated CuSnanoparticles with tunable near-infrared absorption and enhanced relaxivity for in vivo dual-modal photoacoustic/MR imaging." Nanoscale, 7, 17631-17636(2015) (SCI, IF=7.760).

[12]Changho Lee, Jeesu Kim, Yumiao Zhang, MansikJeon, Chengbo Liu, Liang Song, Jonathan F Lovell, Chulhong Kim, "Dual-color photoacoustic lymph node imaging using nanoformulatednaphthalocyanines." Biomaterials, 73, 142-148(2015) (SCI, IF=8.312)

2014

[11] [Huina Wang, Chengbo Liu]¹, Xiaojing Gong, Dehong Hu, Riqiang Lin, Zonghai Sheng, Cuifang Zheng, Meng Yan, Jingqin Chen, Lintao Cai, Liang Song*, "In vivo photoacoustic molecular imaging of breast carcinoma with folate receptor-targeted indocyanine green nanoprobes," Nanoscale, 6, 14270-14279 (2014) (SCI, IF=6.739)

[10] Jia Jian, Chengbo Liu, Yuping Gong, Lei Su, Bin Zhang, Zhigang Wang, Dong Wang, Yu Zhou, Fenfen Xu, Pan Li, Yuanyi Zheng, Liang Song*, Xiyuan Zhou*, "India ink incorporated multifunctional phase-transition nanaodroplets for photoacoustic/ultrasound dual-modality imaging and photoacoustic effect based tumor therapy," Theranostics, 4, 1026-1038 (2014) (SCI, IF=7.827)

4. Theoretical Foundations and Mechanism of Photoacoustic Imaging

2021

[9] Rongkang Gao, Zhiqiang Xu, Yaguang Ren, Liang Song, Chengbo Liu*, "Nonlinear mechanisms in photoacoustics—Powerful tools in photoacoustic imaging." Photoacoustics, 22: 100243, 2021. (SCI, IF=8.484)

[8] [RongkangGao, ZhiqiangXu]¹, LiangSong, Chengbo Liu*, "Breaking Acoustic Limit of Optical Focusing Using Photoacoustic-Guided Wavefront Shaping", Laser & Photonics Reviews, 15(8): 2000594, 2021. (SCI, IF=13.138)

5.Other Topics

[7]  [Huangxuan Zhao, Zhenghong Zhou, Feihong Wu, Dongqiao Xiang]¹, Hui Zhao, Wei Zhang, Lin Li, Zhong Li, Jia Huang, Hongyao Hu, Chengbo Liu, Tao Wang, Wenyu Liu, Jinqiang Ma*, Fan Yang*, Xinggang Wang*, Chuansheng Zheng*, "Self-supervised learning enables 3D digital subtraction angiography reconstruction from ultra-sparse 2D projection views: A multicenter stud", Cell report medicine, 3(10): 100775, 2022. (SCI, IF=16.988)

[6] Zhihua Xie, Chengyou Shu, Daya Yang, Hao Chen, Chaobin Chen, Gang Dai, Kwok Ho Lam, Jinke Zhang, Xiatian Wang, Zonghai Sheng, Duyang Gao, Chengbo Liu, Liang Song*, Xiaojing Gong*, "In vivo intravascular photoacoustic imaging at a high speed of 100 frames per second", Biomedical Optics Express, 11(11): 6721-6731, 2020. (SCI, IF=3.921)

[5] Yan Li, Riqiang Lin, Chengbo Liu, Jianhua Chen, Huadong Liu, Rongqin Zheng, Xiaojing Gong*, Liang Song*, "In vivo photoacoustic/ultrasonic dual-modality endoscopy with a miniaturized full field-of-view catheter." Journal of Biophotonics, e201800034, 2018. (SCI, IF=3.914)

[4] [Yan Li, Xiaojing Gong]¹, Chengbo Liu, Riqiang Lin, William Hau, Xiaosong Bai, Liang Song*, "High-speed intravascular spectroscopic photoacoustic imaging at 1000 A-lines per second with a 0.9 mm diameter catheter." Journal of Biomedical Optics, 20(6), 065006, 2015. (SCI, IF=2.752)

[3] Xiaosong Bai, Xiaojing Gong, William Hau, Riqiang Lin, Jiaxiang Zheng, Chengbo Liu, Chengzhi Zeng, Xin Zou, Hairong Zheng, Liang Song*. "Intravascular optical-resolution photoacoustic tomography with a 1.1 mm diameter catheter.” PLOS One, 9, e92463-e92463, 2014, (SCI, IF=4.24)

[2] Chengbo Liu, Narasimhan Rajaram*, Karthik Vishwanath, Tony Jiang, Gregory M Palmer, Nirmala Ramanujam, "Experimental validation of an inverse fluorescence Monte Carlo model to extract concentrations of metabolically relevant fluorophores from turbid phantoms and a murine tumor model", Journal of Biomedical Optics,17(7): 077012, 2012(SCI, IF=3.5)

[1] Chengbo Liu*, Zheng Li, Zhenxi Zhang. "Mechanisms of laser nanoparticle-based techniques for gene transfection-a calculation study", Journal Of Biological Physics, 35(3): 309, 2009. (SCI, IF=1.8)